The Bounce-Back Effect: What Happens After Cessation of Low-Dose Semaglutide in People with HIV

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Analysis shows weight regain in people with HIV after stopping low-dose semaglutide, suggesting potential loss of cardiometabolic benefits.

Weight regain of 2.9 kg occurred after 24 weeks cessation of semaglutide, highlighting metabolic challenges.
Weight loss was 7.8 kg over 24 weeks with improvements in cardiometabolic factors initially measured.
Analysis using linear regression evaluated changes in weight, blood pressure, glucose, and cholesterol levels after treatment.
Calls for further research on higher-dose semaglutide to sustain cardiometabolic benefits post-treatment.

Erlandson et al. (2025) studied this question.

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Analysis shows weight regain in people with HIV after stopping low-dose semaglutide, suggesting potential loss of cardiometabolic benefits.