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This study aims to evaluate the relationship between serum magnesium and the risks of hyperglycemia, type 2 diabetes, and prediabetes.

Serum magnesium and risk of hyperglycemia, type 2 diabetes, and prediabetes: a systematic review and dose-response meta-analysis of observational studies

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Systematic review examines the link between serum magnesium levels and risks of hyperglycemia and type 2 diabetes.

This study aims to evaluate the relationship between serum magnesium and the risks of hyperglycemia, type 2 diabetes, and prediabetes.
Systematic review and dose-response meta-analysis of observational studies.
Included 24 studies with varying designs, including cohort and cross-sectional studies.
Utilized epidemiologic data presenting relative risks or odds ratios with 95% confidence intervals.
Cohort studies showed a negative association for hyperglycemia (RR = 0.67; 95% CI: 0.51, 0.78) and T2DM (RR = 0.67; 95% CI: 0.56, 0.82) associated with higher serum magnesium.
Non-cohort studies demonstrated significantly reduced odds for hyperglycemia (OR = 0.43; 95% CI: 0.32, 0.57) and T2DM (OR = 0.34; 95% CI: 0.24, 0.46).
Increasing serum magnesium level resulted in a lower risk of T2DM, suggesting inverse associations, particularly for hyperglycemia and T2DM.

Rashki et al. (2026) studied this question.

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