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July 29, 2026Current Issues in Molecular BiologyOpen Access

The Red Alga Jania rubens DM Extract Modulates Apoptotic and Inflammatory Pathways to Enhance Chemotherapeutic Response in Colorectal Cancer Cells

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Authors

ZRZeina RadwanAmerican University of BeirutMMMaysam MoussaUniversity of BalamandSIShaza Khatib IbrahimUniversity of Balamand

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Implication

Randomized trial investigates Jania rubens DM extract's effects on apoptosis and inflammatory pathways in colorectal cancer, suggesting enhanced treatment response.

Key Points

  • This research aims to investigate the effects of Jania rubens DM extract on apoptotic and inflammatory pathways in enhancing chemotherapy responses in colorectal cancer cells.
  • Utilized HCT-116, Caco-2, and HT-29 colorectal cancer cell lines for treatment assessment.
  • Conducted flow cytometric analysis to measure apoptosis and Western blot analysis for BCL-2 protein expression.
  • Evaluated mRNA levels of cytokines (TNF-α, IL-6, IL-10) post-treatment.
  • Combination treatment with DM extract and CAP in HCT-116 and Caco-2 cells significantly improved cytotoxic effects, reducing long-term clonogenic survival.
  • Flow cytometry showed a dose-dependent increase in apoptosis in HCT-116 cells post-DM treatment.
  • Western blot results indicated reduced BCL-2 expression, demonstrating increased pro-apoptotic activity.

Cite This Study

Radwan et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2c7c8da07d9defa6ac9https://doi.org/10.3390/cimb48080759
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