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July 29, 2026MicroorganismsOpen Access

Epstein–Barr Virus and Multiple Sclerosis: Mechanistic Insights into Virus-Driven Autoimmunity

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Authors

SBStavros BashiardesWeizmann Institute of ScienceGKGeorge KrashiasCyprus Institute of Neurology and GeneticsEEElissa EnglezouCyprus Institute of Neurology and Genetics

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Overview

Review explores how Epstein–Barr virus drives autoimmunity in multiple sclerosis, suggesting crucial insights for understanding disease.

Key Points

  • The aim is to investigate the role of Epstein–Barr virus in the development of multiple sclerosis and its mechanisms of autoimmunity.
  • Summarized current knowledge of Epstein–Barr virus biology.
  • Discussed epidemiological findings linking EBV infection with MS.
  • Examined alterations in EBV-specific immune responses in MS patients.
  • Nearly all individuals with MS are EBV seropositive, indicating a strong association.
  • EBV infection precedes MS onset in longitudinal studies, suggesting a causal link.
  • Identified molecular mimicry involving EBNA1 and CNS proteins as a mechanism for autoimmune responses.

Cite This Study

Bashiardes et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2c7c8da07d9defa6b12https://doi.org/10.3390/microorganisms14081639
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