What question did this study set out to answer?

This study aims to quantitatively assess cerebellar atrophy and network alterations in anti-Yo PCD patients compared to healthy controls and SCA1 patients.

July 29, 2026Journal of NeurologyOpen Access

Spatial analysis of paraneoplastic cerebellar degeneration in ovarian cancer with anti-Yo syndrome and SCA1

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Authors

TKTamara KünzleCentre National de la Recherche Scientifique LRLucas Rincon de la RosaCentre National de la Recherche Scientifique CPClément Vialatte de PemilleUniversité Paris Cité

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Randomized trial assessed cerebellar atrophy and network alterations in ovarian cancer, suggesting potential early biomarkers.

Key Points

This study aims to quantitatively assess cerebellar atrophy and network alterations in anti-Yo PCD patients compared to healthy controls and SCA1 patients.
Analyzed structural MRI data from 11 anti-Yo PCD patients, 17 healthy controls, and 17 SCA1 patients.
Conducted cerebellar lobular segmentation and cortical thickness measurements.
Applied machine learning to evaluate the discriminative power of regional morphometric measures.
Anti-Yo PCD patients showed pronounced anterior cortical thinning, while SCA1 atrophy was milder and more posterior.
Increased node strength and clustering coefficients were observed in PCD, indicating altered network organization.
Regional cerebellar features distinguished PCD, SCA1, and controls with promising AUC values.

Cite This Study

Künzle et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2c7c8da07d9defa6b63 https://doi.org/10.1007/s00415-026-13884-0

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Spatial analysis of paraneoplastic cerebellar degeneration in ovarian cancer with anti-Yo syndrome and SCA1

Discussion

Member takes

Implication

Key Points

Cite This Study

Spatial analysis of paraneoplastic cerebellar degeneration in ovarian cancer with anti-Yo syndrome and SCA1

Discussion

Member takes

Implication

Key Points

Cite This Study

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