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July 29, 2026International Journal of Molecular SciencesOpen Access

Association of Functional ADRB1 (rs1801252) and ADRB2 (rs1042714) Polymorphisms with Primary Open-Angle Glaucoma in a Saudi Cohort

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Authors

AKAltaf A. KondkarTSTahira SultanTATaif A. Azad

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Overview

Case–control study examines genetic polymorphisms' effect on glaucoma risk in Saudi individuals, suggesting implications for risk assessment.

Key Points

  • This study aims to explore the relationship between specific genetic variations and the risk of primary open-angle glaucoma.
  • Case–control design with 418 participants (167 cases, 251 controls)
  • Genotyping using real-time PCR for ADRB1 rs1801252 and ADRB2 rs1042714
  • Analysis of associations using allelic and genotype models based on 412 participants with complete data.
  • ADRB1 rs1801252-G allele associated with increased POAG risk: adjusted OR = 1.93 (95% CI 1.22–3.08; p = 0.005)
  • Dominant model: adjusted OR = 2.13 (95% CI 1.23–3.70; p = 0.007)
  • Combined two-locus analysis indicated increased risk for C–G profile: OR = 1.91 (p = 0.033).

Cite This Study

Kondkar et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2d4c8da07d9defa6c59https://doi.org/10.3390/ijms27156668
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