Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5-LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis

Key Points

This research aims to identify a novel dual inhibitor that targets both 5-LOX and sEH pathways to reduce inflammation in acute pancreatitis.
Identified a tetrahydroquinoline-based compound as a dual inhibitor of 5-LOX and sEH.
Evaluated the compound's effects on inflammation levels and Nrf2 activation in acute pancreatitis models.
The new inhibitor significantly reduced inflammation markers in acute pancreatitis, showing a potent anti-inflammatory response.
Nrf2 activation was enhanced, supporting its role in the anti-inflammatory mechanism.

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Identifies a new dual 5-LOX/sEH inhibitor with anti-inflammatory effects in acute pancreatitis, indicating therapeutic potential.

as a promising anti-inflammatory agent supporting dual 5-LOX/sEH inhibition, coupled with Nrf2 activation, as a viable strategy for AP.

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D’Avino et al. (2026) studied this question.

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