What question did this study set out to answer?

This research aims to explore the associations of HLA class II molecules with susceptibility to rheumatoid arthritis in patients lacking common alleles.

January 1, 1991Lara D. Veeken

LIMITED HETEROGENEITY OF THE HLA CLASS II CONTRIBUTION TO SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IS SUGGESTED BY POSITIVE ASSOCIATIONS WITH HLA—DR4, DR1 AND DRwlO

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Authors

BWB. P. WordsworthNuffield Orthopaedic Centre JSJudith StedefordGloucestershire Hospitals NHS Foundation Trust WRWilliam RosenbergCanterbury Christ Church University

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Implication

Randomized trial investigates HLA class II contributions to rheumatoid arthritis susceptibility, suggesting significant associations.

Key Points

This research aims to explore the associations of HLA class II molecules with susceptibility to rheumatoid arthritis in patients lacking common alleles.
Investigated 180 rheumatoid arthritis patients and 100 controls using DNA-based HLA typing.
Utilized sequence-specific oligonucleotides and polymerase chain reaction to identify class II alleles.
Analyzed associations with HLA-DR, DQ, and DP types among the study population.
Significant association with DR4 was found (relative risk 10, P < 0.0001).
Association with DR1 was also significant (relative risk 2.3, P < 0.001).
DRw10 showed a significant association in DR4/DR1-negative RA patients (P = 0.02).

Cite This Study

Wordsworth et al. (1991) studied this question.

synapsesocial.com/papers/6a69db48ba3b67e10e44681f https://doi.org/10.1093/rheumatology/30.3.178

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LIMITED HETEROGENEITY OF THE HLA CLASS II CONTRIBUTION TO SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IS SUGGESTED BY POSITIVE ASSOCIATIONS WITH HLA—DR4, DR1 AND DRwlO

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Key Points

Cite This Study

LIMITED HETEROGENEITY OF THE HLA CLASS II CONTRIBUTION TO SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IS SUGGESTED BY POSITIVE ASSOCIATIONS WITH HLA—DR4, DR1 AND DRwlO

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Cite This Study

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