Key result
In a rat model of myocardial infarction, infarct size measured by Gd-mesoporphyrin-enhanced MRI correlated closely with postmortem measurements (r=0.94, P<0.001) and predicted LV remodeling.
Why the study?
Does contrast-enhanced MRI using Gd-mesoporphyrin and Gd-DTPA accurately predict left ventricular remodeling and infarct size in a rat model of reperfused myocardial infarction?
Population
27 rats with myocardial infarction induced by 1 hour of coronary occlusion/reperfusion
Comparison
Contrast-enhanced MRI using Gd-mesoporphyrin… vs Postmortem measurements of true infarct size and…
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothesis-generating for MRI infarct sizing in rodent MI; human validation required before clinical remodeling prediction.
Does contrast-enhanced MRI using Gd-mesoporphyrin and Gd-DTPA accurately predict left ventricular remodeling and infarct size in a rat model of reperfused myocardial infarction?
Effect estimate: r = 0.94
p-value: p=<0.001
Contrast-enhanced MRI can noninvasively determine initial myocardial injury size and predict subsequent left ventricular remodeling in a rat model of reperfused infarction.
Watzinger et al. (2002) studied Myocardial infarction (n=27). Contrast-enhanced MRI (Gd-mesoporphyrin and Gd-DTPA) vs. Postmortem measurements was evaluated on Correlation between contrast-enhanced MRI and postmortem measurements for infarct size (r = 0.94, p=<0.001). In a rat model of myocardial infarction, infarct size measured by Gd-mesoporphyrin-enhanced MRI correlated closely with postmortem measurements (r=0.94, P<0.001) and predicted LV remodeling.
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