Key result
Glucose lowering fails to reduce cardiovascular disease outcomes across prospective trials.
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Editor comments on the lowered criterion for impaired fasting glucose and its cardiovascular disease implications.
Editor’s comment: Because of the controversial nature of the new lowered criterion for IFG, I offered the Chairman of the Expert Committee an opportunity to respond to my commentary on the subject. I would only point out that Dr. Genuth’s reference 8 shows an association between glycemia and cardiovascular disease (as have many other reports), but to date, five prospective studies, analyzed either singly or as a metanalysis, have been unable to demonstrate a beneficial effect of lowering glycemia on cardiovascular disease outcomes.
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Saul Genuth (2003) conducted an editorial in Impaired Fasting Glucose. Lowering glycemia was evaluated. Lowering glycemia failed to demonstrate a beneficial effect on cardiovascular disease outcomes across five prospective studies, whether analyzed singly or as a meta-analysis.
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