Key result
Poliovirus infection of HeLa cells leads to the specific degradation of at least 14 cellular proteins, a process requiring active viral replication and independent of host translation shutoff.
Population
HeLa cells
Comparison
Poliovirus infection vs Infection with encephalomyocarditis virus or…
Design
Preclinical
Authors
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May indicate poliovirus proteinases degrade select host proteins; leaves open their role in pathogenesis.
Active poliovirus replication causes specific degradation of several host cellular proteins, independent of host translation shutoff.
Urzainqui et al. (1989) studied Poliovirus infection. Poliovirus infection vs. Encephalomyocarditis virus or Semliki Forest virus was evaluated on Degradation of cellular proteins. Poliovirus infection of HeLa cells leads to the specific degradation of at least 14 cellular proteins, a process requiring active viral replication and independent of host translation shutoff.
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