Key result
Elevated neutrophil-lymphocyte ratio (>5.7) and platelet-lymphocyte ratio (>272.9) at admission were independently associated with increased 30-day mortality in patients with acute decompensated heart failure (OR 3.63 and 3.22, respectively).
Why the study?
The study was conducted to investigate the association between both neutrophil to lymphocyte ratio and platelet to lymphocyte ratio and 30-day mortality in patients hospitalized for acute decompensated heart failure.
Do neutrophil-lymphocyte and platelet-lymphocyte ratios predict 30-day mortality in patients hospitalized for acute decompensated heart failure?
Population
439 patients admitted to the ED for an episode of ADHF
Comparison
NLR and PLR levels at admission
Design
Observational cohort study
Follow-up
30 days
Authors
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May aid short-term prognostication in ADHF; leaves open prospective validation before clinical adoption.
Observational (n=439)
No
Do neutrophil-lymphocyte and platelet-lymphocyte ratios predict 30-day mortality in patients hospitalized for acute decompensated heart failure?
Odds Ratio: 3.63 (95% CI 1.49–5.89)
p-value: p=0.005
NLR and PLR at ED admission are independent predictors of 30-day mortality in patients with acute decompensated heart failure, offering a simple prognostic tool.
Turcato et al. (2019) conducted an observational in Acute decompensated heart failure (n=439). Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) vs. Lower NLR and PLR values was evaluated on 30-day mortality (OR 3.63, 95% CI 1.49-5.89, p=0.005). Elevated neutrophil-lymphocyte ratio (>5.7) and platelet-lymphocyte ratio (>272.9) at admission were independently associated with increased 30-day mortality in patients with acute decompensated heart failure (OR 3.63 and 3.22, respectively).
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