Key result
Sustained AAV vector-mediated IL-10 expression significantly improved the survival rate of Dahl salt-sensitive rats compared with EGFP expression (62.5% vs 0%, p<0.001).
Why the study?
Does AAV vector-mediated IL-10 expression improve survival and reduce hypertensive organ damage in Dahl salt-sensitive rats?
Population
Dahl salt-sensitive rats fed a high-sodium diet from 6 weeks of age
Comparison
Adeno-associated virus type 1-based vector… vs AAV vector encoding enhanced green fluorescent…
Design
Preclinical
Follow-up
15 weeks
Authors
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Sustained IL-10 expression attenuates hypertensive organ damage in rats; leaves open translation to human hypertension.
Does AAV vector-mediated IL-10 expression improve survival and reduce hypertensive organ damage in Dahl salt-sensitive rats?
Absolute Event Rate: 62.5% vs 0%
p-value: p=<0.001
AAV vector-mediated systemic IL-10 expression improves survival, reduces blood pressure, and ameliorates hypertensive heart and renal damage in a rat model of salt-sensitive hypertension.
Nonaka‐Sarukawa et al. (2008) studied Hypertensive heart disease and renal dysfunction. Adeno-associated virus (AAV) type 1-based vector encoding rat IL-10 vs. Enhanced green fluorescent protein (EGFP) was evaluated on Survival rate (p=<0.001). Sustained AAV vector-mediated IL-10 expression significantly improved the survival rate of Dahl salt-sensitive rats compared with EGFP expression (62.5% vs 0%, p<0.001).
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