What question did this study set out to answer?

To explore the effects of triple deficiency of VLDLR, LDLR, and LRP on triglyceride-rich lipoprotein metabolism in mice.

March 17, 2005Journal of Lipid ResearchOpen Access

Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice

Q: What is the clinical evidence from this study?

Study design: Other. Population: Hyperlipidemia. Intervention: VLDLR, LDLR, and LRP triple deficiency vs. Wild-type mice and LDLR/LRP double-deficient mice. Primary outcome: Plasma lipids, lipases, and postprandial TG clearance.

View Full Paper

Ask AI

Bookmark

Key result

VLDLR, LDLR, and LRP triple-deficient mice showed markedly delayed postprandial triglyceride clearance on a hyperlipidemic background, without aggravating hyperlipidemia versus double-deficient mice.

Population

VLDLR, LDLR, and LRP triple-deficient mice

Comparison

Genetic knockout of VLDLR, LDLR, and LRP vs Wild-type mice, and LDLR and LRP…

Design

Preclinical

Authors

SSSonia M.S. Espirito SantoLeiden University Medical Center PRPatrick C.N. RensenLeiden University Medical Center JGJeltje R. GoudriaanLeiden University Medical Center

Discussion

Member takes

Implication

Does not aggravate hyperlipidemia in LDLR/LRP-deficient mice; leaves open translational relevance of this triple-knockout model for TG clearance.

Key Points

To explore the effects of triple deficiency of VLDLR, LDLR, and LRP on triglyceride-rich lipoprotein metabolism in mice.
Generated triple-deficient mice lacking VLDLR, LDLR, and LRP receptors.
Compared plasma lipid levels between triple-deficient mice and wild-type controls.
Assessed postprandial triglyceride clearance after high-fat diet feeding.
Triple-deficient mice accumulated significant plasma lipids compared to wild-type mice.
Showed decreased postprandial TG clearance consistent with VLDLR-deficient mice.
TG levels increased following high-fat diet but did not exacerbate hyperlipidemia compared to double-deficient mice.

Structured PICO

Population

VLDLR, LDLR, and LRP triple-deficient mice compared with wild-type and double-deficient mice to study triglyceride-rich lipoprotein metabolism.

Exposure

Genetic knockout of VLDLR, LDLR, and LRP (with high-fat diet feeding challenge)

Comparator

Wild-type mice, and LDLR and LRP double-deficient mice

Outcome

Plasma lipid levels, lipase levels, and postprandial triglyceride clearancesurrogate

VLDLR, LDLR, and LRP triple-deficient mice represent a unique model of markedly delayed triglyceride clearance on a hyperlipidemic background.

Cite This Study

Santo et al. (2005) studied Hyperlipidemia. VLDLR, LDLR, and LRP triple deficiency vs. Wild-type mice and LDLR/LRP double-deficient mice was evaluated on Plasma lipids, lipases, and postprandial TG clearance. VLDLR, LDLR, and LRP triple-deficient mice showed markedly delayed postprandial triglyceride clearance on a hyperlipidemic background, without aggravating hyperlipidemia versus double-deficient mice.

synapsesocial.com/papers/6a69edfb8f877d048bf15a21 https://doi.org/10.1194/jlr.c500007-jlr200

View Full Paper

Ask AI

Bookmark

Implication

Does not aggravate hyperlipidemia in LDLR/LRP-deficient mice; leaves open translational relevance of this triple-knockout model for TG clearance.

Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider