Key result
Removal of a single LSR allele in mice caused statistically significant increases in plasma triglyceride and cholesterol levels and delayed clearance of lipid emulsions.
Population
LSR mice, LSR mice lacking functional LDL receptors, and mouse Hepa1-6 cells
Comparison
Removal of a single LSR allele (LSR mice) and… vs Control mice (wild-type) on the same diet
Design
Preclinical
Authors
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Heterozygous LSR loss elevates lipids in mice; leaves open its role in human dyslipidemia.
LSR plays a critical role in the physiological clearance of atherogenic triglyceride-rich lipoproteins and LDL, suggesting it as a potential therapeutic target for hyperlipidemia.
Yen et al. (2008) studied Hyperlipidemia. Removal of a single LSR allele (LSR(-/+)) vs. Control mice was evaluated on Plasma triglyceride and cholesterol levels. Removal of a single LSR allele in mice caused statistically significant increases in plasma triglyceride and cholesterol levels and delayed clearance of lipid emulsions.
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