Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR–/– embryos at 12.5 to 14.5 days of gestation

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Population

Adult and embryonic mice (129/Ola-C57BL/6) and 129/Ola ES cells

Comparison

Inactivation of the lipolysis stimulated… vs Wild-type and heterozygote littermates

Design

Preclinical

Authors

Discussion

LSR is essential for murine embryogenesis; leaves open its viability as a therapeutic target in adult humans.

Population

Adult and embryonic mice (129/Ola-C57BL/6) and 129/Ola ES cells

Intervention

Inactivation of the lipolysis stimulated receptor (LSR) gene (deletion of exons 2-5)

Comparator

Wild-type and heterozygote littermates

Outcome

Embryonic viability and tissue distribution of LSR

LSR expression is critical for liver and embryonic development in mice, as its inactivation leads to embryonic lethality.

Mesli et al. (2004) studied this question.

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