Key result
Decreasing pO2 to < 2.0 mmHg induced a 1.5-fold increase in lactate production in human platelets, indicating the Pasteur effect is unlikely to cause platelet death during standard storage.
Why the study?
Does the Pasteur effect occur in human platelets at typical storage oxygen concentrations?
Population
Human platelets (defined platelet preparation)
Comparison
Exposure to varying oxygen concentrations vs Different oxygen concentrations
Design
Preclinical
Authors
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May reassure on current platelet storage oxygenation; leaves open primary drivers of storage-related platelet dysfunction.
Does the Pasteur effect occur in human platelets at typical storage oxygen concentrations?
Effect estimate: 1.5-fold increase
The Pasteur effect is unlikely to be a major cause of platelet death during storage, as it only occurs at oxygen concentrations much lower than those typically found in storage bags.
Guppy et al. (1995) studied Platelet storage. Decreased oxygen concentration (pO2 < 2.0 mmHg) vs. Saturating oxygen concentrations was evaluated on Lactate production (Pasteur effect) (1.5-fold increase). Decreasing pO2 to < 2.0 mmHg induced a 1.5-fold increase in lactate production in human platelets, indicating the Pasteur effect is unlikely to cause platelet death during standard storage.
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