Key result
Platelet lesions during prolonged storage correlate highly with ATP depletion and energy metabolism failure.
Why the study?
The nature and progression of platelet storage lesion in second-generation containers using various storage media and durations up to 14 days was not fully characterized.
Population
Platelet concentrates stored in second-generation containers
Design
Preclinical experimental study
Follow-up
Up to 14 days
Authors
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May identify ATP metabolism as a target to mitigate platelet storage lesions; leaves open translation to human transfusion practice.
Platelet storage lesions in second-generation containers appear to be driven by a failure in platelet energy metabolism, as evidenced by the strong correlation with ATP depletion.
Holme et al. (1987) studied Platelet storage lesion. Storage media modifications (sodium bicarbonate or plasma-free physiologic salt solution) vs. CPD-plasma (control medium) was evaluated on Platelet lesion parameters (shape, count, LDH, oxygen consumption, ATP, hypotonic shock response). Platelet lesions during prolonged storage in second-generation containers correlate highly with ATP depletion and failure in platelet energy metabolism.
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