Why the study?
Does storage of platelet concentrates for 72 hours at 22 degrees C affect adenine nucleotide content and granular secretion compared to fresh platelets?
Population
Platelet concentrates (PC) (n=34 with 50 ml volume, n=11 with 30 ml volume, n=16 for metabolic pool labeling)
Comparison
Storage for 72 hours at 22 degrees C vs Fresh platelets (before storage)
Design
Preclinical
Follow-up
72 hours
Authors
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Storage impairs adenine nucleotides and alpha-granule release in this model; leaves open effects on human platelet transfusion outcomes.
Does storage of platelet concentrates for 72 hours at 22 degrees C affect adenine nucleotide content and granular secretion compared to fresh platelets?
Stored platelets develop an acquired defect in both dense and alpha granules and in their ability to maintain ATP homeostasis.
Rao et al. (1981) studied this question.
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