Key result
Storage of human platelets at 22 C for up to 72 hours showed no appreciable change in glycogen content or adenylate charge, but further storage led to progressive loss of adenylate and glycogen.
Population
Human platelets
Comparison
Extended storage at 22 C with continuous agitation vs Freshly prepared platelets (baseline)
Design
Preclinical
Follow-up
>72 hours
Authors
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Early platelet dysfunction at 22°C storage is independent of energy depletion; leaves open mechanisms and human transfusion implications.
Early impairment of platelet function during storage at 22 C is not due to alterations in energy metabolism, though prolonged storage depletes glycogen and adenylate.
Orengo et al. (1980) studied this question. Extended storage at 22 C with continuous agitation vs. Freshly prepared platelets was evaluated on Glycogen and adenine nucleotide metabolism. Storage of human platelets at 22 C for up to 72 hours showed no appreciable change in glycogen content or adenylate charge, but further storage led to progressive loss of adenylate and glycogen.
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