January 1, 1983BloodOpen Access

Thrombin and ionophore A23187-induced dense granule secretion in storage pool deficient platelets: evidence for impaired nucleotide storage as the primary dense granule defect

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Population

Gel-filtered platelets from patients with storage pool deficiency (SPD) and normal platelets

Comparison

Thrombin and divalent cation ionophore A23187 vs Normal platelets

Design

Preclinical

Authors

Discussion

May refine SPD platelet testing; leaves open nucleotide transport defects as primary mechanism.

Population

Gel-filtered platelets from patients with storage pool deficiency (SPD) and normal platelets

Intervention

Thrombin and divalent cation ionophore A23187

Comparator

Normal platelets

Outcome

Secretion of dense granule constituents (ATP, ADP, calcium, pyrophosphate, orthophosphate) and release of magnesiumsurrogate

The study suggests that impaired nucleotide transport and/or storage may be the primary dense granule defect in storage pool deficiency.

Lages et al. (1983) studied this question.

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