Why the study?
What is the role of dense granule adenosine diphosphate (ADP) in mediating platelet aggregation by epinephrine in patients with storage pool deficiency?
Population
10 patients with storage pool deficiency (SPD) specific to the dense granules (delta-SPD) and normal subjects
Comparison
Epinephrine and Tx receptor agonist U44069 vs Normal subjects
Design
Other
Authors
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Does not alter platelet testing protocols in storage pool deficiency; leaves open in vivo validation of ADP-TxA2 synergy.
What is the role of dense granule adenosine diphosphate (ADP) in mediating platelet aggregation by epinephrine in patients with storage pool deficiency?
Dense granule-derived ADP acts as a synergistic agonist with TxA2 to mediate secondary platelet aggregation by epinephrine, but is not required for primary aggregation.
Weiss et al. (1988) studied this question.
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