Key result
A male subject exhibited a platelet defect with absent adrenaline-induced aggregation and lack of secondary aggregation to ADP and PAF, but no bleeding tendency due to synergistic agonist responses.
Population
1 male subject without a significant bleeding tendency
Design
Case_report
Authors
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May not indicate bleeding risk despite absent adrenaline aggregation; leaves open compensatory roles of synergistic agonists in vivo.
Case Report (n=1)
Describes a specific platelet aggregation defect that does not cause clinical bleeding, likely because multiple subthreshold agonists in vivo can overcome the single-agonist defect.
Anfossi et al. (1991) conducted a case report in Platelet defect (n=1). Platelet defect was evaluated on Platelet aggregation response to various stimuli. A male subject exhibited a platelet defect with absent adrenaline-induced aggregation and lack of secondary aggregation to ADP and PAF, but no bleeding tendency due to synergistic agonist responses.
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