Platelet‐activating factor is a weak platelet agonist: Evidence from normal human platelets and platelets with congenital secretion defects

Normal human platelets and platelets from three groups of patients with congenital secretion defects (storage pool deficiency, impaired thromboxane synthesis due to impaired liberation of AA, and impaired secretion despite normal granule stores and thromboxane production)

Platelet activating factor (PAF) 10(-5) M

Thrombin 5 U/ml (for thromboxane synthesis comparison)

Platelet activation (including irreversible aggregation, 14C-serotonin secretion, arachidonic acid mobilization, thromboxane synthesis, and phosphatidic acid formation)surrogate