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March 1, 1982Blood

Effect of platelet-activating factor (PAF) on human platelets

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Population

Human platelets, n=9 for secretion assays

Design

Preclinical

Authors

CCCM ChesneyBaptist Memorial HospitalDPDD PiferBaptist Memorial HospitalLBLW ByersBaptist Memorial Hospital

Discussion

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Overview

Cyclo-oxygenase inhibitors may blunt PAF platelet effects; animal data leave open clinical translation.

Structured PICO

P
Population
Human platelets (platelet-rich plasma or platelet suspension obtained by gel-filtration), n=9 for secretion assays
I
Intervention
Pure synthetic platelet-activating factor (PAF) (0.2-2.0 micrograms/ml)
O
Outcome
Platelet aggregation and secretion of 14C-serotonin and platelet factor 4 (PF4)surrogate

The major effect of PAF on human platelets appears to be mediated through the cyclo-oxygenase pathway.

Cite This Study

Chesney et al. (1982) studied this question.

synapsesocial.com/papers/6a84a6bc00d9db48ed0cc617https://doi.org/10.1182/blood.v59.3.582.582
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).1979 · 1,207 citations
  2. 2Physicochemical and Functional Identity of Rabbit Platelet-Activating Factor (PAF) Released in Vivo during IgE Anaphylaxis with PAF Released in Vitro from IgE Sensitized Basophils1979 · 449 citations
  3. 3Some Effects of Fibrinogen Degradation Products (FDP) on Blood Platelets1966 · 156 citations
  4. 4Subcellular localization and secretion of factor V from human platelets.1981 · 90 citations
  5. 5LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS1972 · 1,227 citations