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November 1, 1980British Journal of Haematology

Platelet‐Activating Factor (PAF‐Acether) Secretion from Platelets: Effect of Aggregating Agents

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Key result

Stimulation of washed rabbit platelets with calcium ionophore A23187, thrombin, and collagen induced PAF-acether formation, suggesting it may mediate ADP- and TxA2-independent aggregation.

Population

Washed rabbit platelets

Comparison

Stimulation with calcium ionophore A23187… vs Stimulation with ADP, arachidonic acid, and…

Design

Preclinical

Authors

MCMichel ChignardUniversité Paris-SudJCJ P Le CouedicInsermBVB.B. VargaftigUniversidade de São Paulo

Discussion

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Overview

May implicate PAF in ADP/TxA2-independent aggregation; hypothesis-generating, leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Washed rabbit platelets
I
Intervention
Stimulation with calcium ionophore A23187, thrombin, and collagen
C
Comparator
Stimulation with ADP, arachidonic acid, and PAF-acether
O
Outcome
Formation/secretion of PAF-acethersurrogate

PAF-acether is secreted by rabbit platelets upon stimulation with specific agents, suggesting it may mediate ADP- and TxA2-independent platelet aggregation.

Cite This Study

Chignard et al. (1980) studied this question. Calcium ionophore A23187, thrombin, and collagen vs. ADP, arachidonic acid, and PAF-acether was evaluated on PAF-acether formation. Stimulation of washed rabbit platelets with calcium ionophore A23187, thrombin, and collagen induced PAF-acether formation, suggesting it may mediate ADP- and TxA2-independent aggregation.

synapsesocial.com/papers/6a6c185201245da06ecbb258https://doi.org/10.1111/j.1365-2141.1980.tb05993.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Further Evidence for the Role of Thrombin in the Platelet Release Reaction Caused by Various Agents, and the Nature of Biphasic Platelet Aggregation1978 · 7 citations
  2. 2Carrageenan and thrombin trigger prostaglandin synthetase-independent aggregation of rabbit platelets: inhibition by phospholipase A2 inhibitors1977 · 88 citations
  3. 3Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.1975 · 3,060 citations
  4. 4Release of 14C-serotonin during initial platelet changes induced by thrombin, collagen, or A231871977 · 113 citations
  5. 5Interrelations of Platelet Aggregation and Secretion1977 · 344 citations