December 21, 1984Science

Platelet-Activating Factor-Induced Aggregation of Human Platelets Specifically Inhibited by Triazolobenzodiazepines

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Population

Washed human platelets

Design

Preclinical

Authors

Discussion

Triazolobenzodiazepines should not alter clinical antiplatelet practice; extends in vitro tools for probing PAF platelet signaling.

Population

Washed human platelets

Intervention

Triazolobenzodiazepine drugs (alprazolam and triazolam)

Outcome

Inhibition of PAF-induced changes in shape, aggregation, and secretionsurrogate

Triazolobenzodiazepines specifically inhibit PAF-induced platelet aggregation, providing a tool to study PAF-mediated biochemical mechanisms.

Kornecki et al. (1984) studied this question.

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