Population
Human platelets in plasma or blood
Comparison
Paf-acether and adrenaline vs Aspirin (in vitro or oral ingestion)
Design
Preclinical
Authors
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May indicate aspirin-resistant platelet pathways in animals; leaves open relevance to human thrombosis or therapy.
Paf-acether and adrenaline synergistically induce platelet aggregation through cyclo-oxygenase-independent pathways that are not fully inhibited by aspirin.
Fouque et al. (1984) studied this question.
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