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February 1, 1988Blood

Despite diminished alpha 2-adrenergic receptors in patients, epinephrine-induced inhibition of cAMP levels was similar to normal subjects (IC50 0.04 +/- 0.01 mumol/L vs 0.03 +/- 0.01 mumol/L, p>0.05).

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Population

Family members with an inherited platelet alpha 2-adrenergic receptor defect and normal subjects.

Comparison

In vitro exposure of platelets to epinephrine… vs Platelets from normal subjects.

Design

Other

Authors

ARA. Koneti RaoJWJ WillisMKM. Anna Kowalska

Discussion

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Overview

Platelet cAMP response to epinephrine is preserved despite fewer receptors; leaves open whether this affects aggregation or clinical outcomes.

Structured PICO

P
Population
Family members with an inherited platelet alpha 2-adrenergic receptor defect (propositus, 2 sisters, parents, 2 maternal aunts; n=7) and normal subjects (n=12).
I
Intervention
In vitro exposure of platelets to epinephrine, yohimbine, thrombin, and PGI2 analog ZK 36,374.
C
Comparator
Platelets from normal subjects.
O
Outcome
Platelet alpha 2-adrenergic receptor density and epinephrine-induced inhibition of adenylate cyclase (cAMP levels).surrogate

This mechanistic study demonstrates that fewer platelet alpha 2-adrenergic receptors are required for epinephrine-induced inhibition of adenylate cyclase than for platelet aggregation.

Cite This Study

Rao et al. (1988) studied this question.

synapsesocial.com/papers/6a89538c6fc170cbc2fb983ehttps://doi.org/10.1182/blood.v71.2.494.494
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of the 2A –adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro2001 · 16 citations
  2. 2Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E1, and guanine nucleotides. Evidence for separate guanine nucleotide sites mediating stimulation and inhibition.1979 · 108 citations
  3. 3Impaired responsiveness of platelets to epinephrine due to α2A adrenoreceptor deficiency in Male Chinese2015 · 7 citations
  4. 4Epinephrine‐induced platelet aggregation. A twin study**1984 · 33 citations
  5. 5Induction of human platelet fibrinogen receptors by epinephrine in the absence of released ADP1982 · 52 citations