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January 1, 2001Platelets

Activation of the 2A –adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro

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Population

Human platelet-rich plasma in vitro

Design

Preclinical

Authors

TMTodd Schwarz Saul Maayani

Discussion

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Overview

May link sympathetic activation to thrombotic risk; hypothesis-generating for human alpha(2A) targeting.

Structured PICO

P
Population
Human platelet-rich plasma in vitro
I
Intervention
Activation of alpha(2A)-adrenoceptor (with epinephrine or norepinephrine) combined with ADP P2Y(1) or 5-HT(2A) receptor activation
O
Outcome
Time course of the aggregation response (specifically the rate constant of deaggregation)surrogate

Alpha(2A)-adrenoceptor activation by epinephrine or norepinephrine decelerates platelet deaggregation, which may contribute to increased thrombotic risk in certain disease states.

Cite This Study

Todd Schwarz Saul Maayani (2001) studied this question.

synapsesocial.com/papers/6a89b86e755d28965dfd5242https://doi.org/10.1080/09537100120078403
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Also Consider

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  1. 1Activation of G i -coupled receptors releases a tonic state of inhibited platelet aggregation2001 · 12 citations
  2. 2Platelet alpha2 adrenoceptor characteristics during the morning increase in platelet aggregability1992 · 21 citations
  3. 3Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation1999 · 118 citations
  4. 4Effects of Ticlopidine Administered to Healthy Volunteers on Platelet Function in Whole Blood1995 · 40 citations
  5. 5Evidence for Prothrombotic Effects of Exercise and Limited Protection by Aspirin1999 · 140 citations