Population
In vitro platelet preparations (representative published data supplemented with original laboratory data)
Comparison
Adenosine diphosphate at various concentrations… vs Different ADP concentrations or unblocked state
Design
Preclinical
Authors
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P2Y12 blockade may enhance platelet deaggregation kinetics; hypothesis-generating for inhibitor mechanisms, needs human validation.
This in vitro kinetic study demonstrates that platelet deaggregation is an active process that is decelerated by P2Y12 receptor activation, providing mechanistic insight into the effects of P2Y12 inhibitors like clopidogrel.
Maayani et al. (2001) studied this question.
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