January 1, 2001Platelets

The balance of concurrent aggregation and deaggregation processes in platelets is linked to differential occupancy of ADP receptor subtypes

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Population

Human platelet-rich plasma (PRP) prepared in r-hirudin

Design

Preclinical

Follow-up

20 min

Authors

Discussion

Preclinical P2T ADP receptor findings should not change antiplatelet practice; leaves open translation to human platelet dynamics.

Population

Human platelet-rich plasma (PRP) prepared in r-hirudin

Intervention

ADP (adenosine 5'-diphosphate) and 2-MeS-ADP (2-methylthioadenosine-diphosphate)

Outcome

Platelet aggregation and deaggregation measured by optical density (OD) at 580 nmsurrogate

The balance between platelet aggregation and deaggregation is governed by the degree of P2T ADP receptor occupancy.

Maayani et al. (2001) studied this question.

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