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January 1, 2001Platelets

Activation of G i -coupled receptors releases a tonic state of inhibited platelet aggregation

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Population

Platelets (in vitro model)

Design

Preclinical

Authors

SMSaul MaayaniTSTodd E. SchwarzRMRafael Martínez

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Overview

Hypothesis-generating for platelet signaling; leaves open in vivo translation and clinical antiplatelet implications.

Structured PICO

P
Population
Platelets (in vitro model)
I
Intervention
Activation of Gi-coupled receptors (ADP P2T or alpha2-adrenoceptor) and Gq-coupled receptors (ADP P2Y1 or 5-HT2A)
O
Outcome
Platelet aggregation response and its fadesurrogate

Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation, providing a mechanistic explanation for the regulation of ADP-induced platelet aggregation.

Cite This Study

Maayani et al. (2001) studied this question.

synapsesocial.com/papers/6a89b86e755d28965dfd5240https://doi.org/10.1080/09537100020032055
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ADP can induce aggregation of human platelets <i>via</i> both P2Y<sub>1</sub> and P<sub><i>2T</i></sub> receptors2000 · 87 citations
  2. 2Role of P2Y1 purinoceptor in ADP‐induced platelet activation1998 · 195 citations
  3. 3The P2Y<sub>1</sub> receptor, necessary but not sufficient to support full ADP‐induced platelet aggregation, is not the target of the drug clopidogrel1998 · 143 citations
  4. 4Cyclic Nucleotides and Phosphodiesterases in Platelets1999 · 163 citations
  5. 5Impaired prostaglandin E1/I2 receptor activity of human blood platelets in acute ischemic heart disease.1990 · 45 citations