Population
Human platelets, rat platelets, and patients with congenital impairment of ADP-induced platelet aggregation
Design
Preclinical
Authors
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Early rat data support dual ADP receptors on platelets; leaves open human translation and targeted antiplatelet strategies.
Pharmacological evidence using clopidogrel and binding studies strongly suggests the presence of two distinct ADP receptors on platelets mediating different activation pathways.
Gachet et al. (1995) studied this question.
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