December 1, 1998British Journal of Haematology

The P2Y1 receptor, necessary but not sufficient to support full ADP‐induced platelet aggregation, is not the target of the drug clopidogrel

View Full Paper

Ask AI

Bookmark

Population

Rats (platelets from control and clopidogrel-treated rats)

Comparison

Clopidogrel and specific P2Y1 antagonists A2P5P… vs Untreated/control rats

Design

Preclinical

Authors

BHBéatrice HechlerInserm AEAnita EcklyInserm POPhilippe OhlmannVascular Medicine

Discussion

Member takes

Implication

P2Y1 should not yet be targeted for clopidogrel-like effects; leaves open a distinct adenylyl cyclase-coupled ADP receptor.

Structured PICO

Population

Rats (platelets from control and clopidogrel-treated rats)

Intervention

Clopidogrel (50 mg/kg) and specific P2Y1 antagonists A2P5P and A3P5P

Comparator

Untreated/control rats

Outcome

ADP-induced platelet aggregation and shape changesurrogate

This preclinical study demonstrates that the P2Y1 receptor is not the target of clopidogrel, pointing to the existence of another P2Y receptor specifically coupled to adenylyl cyclase inhibition.

Cite This Study

Hechler et al. (1998) studied this question.

synapsesocial.com/papers/6a7e194ee78a1cc0dbc7f4c0 https://doi.org/10.1046/j.1365-2141.1998.01056.x

Topics

Dual antiplatelet therapy

View Full Paper

Ask AI

Bookmark

The P2Y1 receptor, necessary but not sufficient to support full ADP‐induced platelet aggregation, is not the target of the drug clopidogrel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The P2Y1 receptor, necessary but not sufficient to support full ADP‐induced platelet aggregation, is not the target of the drug clopidogrel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider