January 1, 1992Thrombosis and Haemostasis

ADP Receptor Induced Activation of Guanine Nucleotide Binding Proteins in Rat Platelet Membranes– An Effect Selectively Blocked by the Thienopyridine Clopidogrel

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Population

rat platelet membranes

Design

Preclinical

Authors

CGChristian GachetGeneral / Preventive / Lipids PSPierre SaviScripps Research Institute POPhilippe OhlmannVascular Medicine

Discussion

Member takes

Implication

Supports irreversible ADP receptor modification by clopidogrel in rats; leaves open translation to human antiplatelet therapy.

Structured PICO

Population

rat platelet membranes

Intervention

clopidogrel

Outcome

stimulation of [35S]GTP gamma S binding to platelet membranes by 2MeSADPsurrogate

Clopidogrel inhibits ADP-induced platelet aggregation by impairing the interaction of the ADP receptor with its G protein through irreversible modification.

Cite This Study

Gachet et al. (1992) studied this question.

synapsesocial.com/papers/6a7f4ea1aa1ae1567cb3d725 https://doi.org/10.1055/s-0038-1656322

Topics

Dual antiplatelet therapy

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ADP Receptor Induced Activation of Guanine Nucleotide Binding Proteins in Rat Platelet Membranes– An Effect Selectively Blocked by the Thienopyridine Clopidogrel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

ADP Receptor Induced Activation of Guanine Nucleotide Binding Proteins in Rat Platelet Membranes– An Effect Selectively Blocked by the Thienopyridine Clopidogrel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider