Key result
Impaired platelet responsiveness to epinephrine was found in 52% of healthy male Taiwanese Chinese volunteers, associated with significantly lower GP IIb/IIIa expression (9.9% vs 27.1%, p=0.003).
Population
50 healthy male Taiwanese Chinese volunteers
Comparison
In vitro epinephrine stimulation of platelets vs Good responders vs. impaired responders
Design
Cross-sectional
Authors
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Suggests ethnic variation in platelet reactivity; leaves open relevance to antiplatelet therapy responses.
Cross-Sectional (n=50)
Absolute Event Rate: 9.9% vs 27.1%
p-value: p=0.003
A high prevalence (52%) of impaired platelet responsiveness to epinephrine was found in healthy Taiwanese Chinese males, likely due to α2A adrenoreceptor deficiency.
Lin et al. (2015) conducted a cross-sectional in Healthy (n=50). Impaired responsiveness to epinephrine vs. Good responsiveness to epinephrine was evaluated on Glycoprotein (GP) IIb/IIIa expression after stimulation with 1 μM epinephrine (p=0.003). Impaired platelet responsiveness to epinephrine was found in 52% of healthy male Taiwanese Chinese volunteers, associated with significantly lower GP IIb/IIIa expression (9.9% vs 27.1%, p=0.003).
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