Key result
Endothelial vascular damage is linked to progressive hemorrhagic necrosis after acute spinal trauma.
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We postulated that damage to the endothelial lining of the spinal cord vasculature is a major factor in the pathogenesis of the characteristic lesion of the spinal cord (progressive, central, hemorrhage necrosis) that occurs after acute trauma. Endothelial damage may occur as a result of primary injury to the vessels or after arterial spasm. This damageresults in deposition of platelets and formation of thrombi on the exposed subendothelial tissues and embolization of such thrombi to smaller vessels of the spinal cord parenchyma.
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Erland Nelson (1977) studied Spinal Cord Injury. Endothelial damage of spinal cord vasculature was evaluated on Progressive, central, hemorrhagic necrosis. Damage to the endothelial lining of the spinal cord vasculature is hypothesized to be a major factor in the pathogenesis of progressive, central, hemorrhagic necrosis after acute trauma.
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