Key result
Transgenic mice expressing ATP-insensitive K(ATP) channels demonstrated a profound tolerance for reduced ATP sensitivity and a 4-fold lower channel density without action potential shortening.
Absolute Event Rate: 2.7% vs 0.051%
Cardiac tissue demonstrates a profound tolerance for reduced ATP sensitivity of K(ATP) channels, contrasting with the effects seen in pancreatic beta-cells.
No takes yet. Share an insight, caveat, or question.
Cardiac tissue tolerates ATP-insensitive K(ATP) channels without action potential shortening; leaves open translation to human ischemia or arrhythmia models.
Koster et al. (2001) studied Cardiac function and K(ATP) channel activity. Expression of GFP-tagged Kir6.2 subunits with reduced ATP sensitivity vs. Littermate controls was evaluated on K(1/2) ([ATP] causing half-maximal inhibition). Transgenic mice expressing ATP-insensitive K(ATP) channels demonstrated a profound tolerance for reduced ATP sensitivity and a 4-fold lower channel density without action potential shortening.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: