Key result
Management strategies for diuretic resistance in heart failure include sodium intake restriction, changes in diuretic dose and route of administration, and sequential nephron diuretic therapy.
This review outlines the mechanisms and management strategies for diuretic resistance in patients with chronic congestive heart failure.
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Diuretic resistance strategies in HF warrant caution; leaves open need for randomized validation of dosing approaches.
Chronic congestive heart failure (CHF) is a complex disorder characterized by inability of the heart to keep up the demands on it, followed by the progressive pump failure and fluid accumulation. Although the loop diuretics are widely used in heart failure (HF) patients, both pharmacodynamic and pharmacokinetic alterations are thought to be responsible for diuretic resistance in these patients. Strategies to overcome diuretic resistance include sodium intake restriction, changes in diuretic dose and route of administration and sequential nephron diuretic therapy. In this review, we discuss the definition, prevalence, mechanism of development and management strategies of diuretic resistance in HF patients.
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Shah et al. (2017) conducted a review in Chronic congestive heart failure. Management strategies for diuretic resistance was evaluated. Management strategies for diuretic resistance in heart failure include sodium intake restriction, changes in diuretic dose and route of administration, and sequential nephron diuretic therapy.
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