Key result
Ganglionic blockade with trimethaphan discriminated between sympathetic-dependent and independent hypertension, lowering SBP below 125 mmHg in MSA patients while remaining elevated in PAF patients.
Why the study?
Does ganglionic blockade with trimethaphan and LF(SBP) measurement discriminate between sympathetic-dependent and independent hypertension?
Population
Patients with multiple system atrophy as positive controls, pure autonomic failure as negative controls…
Comparison
Trimethaphan 2-4 mg/min to induce complete… vs Comparisons across the four different…
Design
Cross-sectional
Authors
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LF(SBP) or post-blockade BP drop may flag sympathetic-driven supine hypertension in MSA; leaves open validation as a marker beyond these rare phenotypes.
Observational
Does ganglionic blockade with trimethaphan and LF(SBP) measurement discriminate between sympathetic-dependent and independent hypertension?
Ganglionic blockade coupled with LF(SBP) measurements can effectively discriminate between sympathetic-dependent and independent hypertension, aiding in the physiological phenotyping of essential hypertension.
Diedrich et al. (2003) conducted an observational in Hypertension. Trimethaphan vs. Normotensive subjects and pure autonomic failure patients was evaluated on Systolic blood pressure (SBP) response to autonomic blockade. Ganglionic blockade with trimethaphan discriminated between sympathetic-dependent and independent hypertension, lowering SBP below 125 mmHg in MSA patients while remaining elevated in PAF patients.
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