Key result
The Gly16/Gly16 beta-2 AR genotype was associated with higher basal mean blood pressure (81.6 vs 75.2 mm Hg, P<0.01) and decreased salbutamol-induced vasodilation compared to the Arg16/Arg16 genotype.
Why the study?
Do beta-2 adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young normotensive Caucasian men?
Observational (n=57)
Observer-blinded
Do beta-2 adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young normotensive Caucasian men?
Absolute Event Rate: 81.6% vs 75.2%
p-value: p=<0.01
The Gly16 allele of the beta-2 adrenergic receptor is associated with higher resting blood pressure and blunted agonist-induced vasodilation, suggesting a potential mechanistic role in the pathogenesis of essential hypertension.
Authors
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May inform ethnic variation in beta-2 AR vasodilation; leaves open its causal role in hypertension.
Gratze et al. (1999) conducted an observational in Normotension (n=57). Gly16/Gly16 beta-2 AR genotype vs. Arg16/Arg16 beta-2 AR genotype was evaluated on Basal mean blood pressure (mm Hg) (p=<0.01). The Gly16/Gly16 beta-2 AR genotype was associated with higher basal mean blood pressure (81.6 vs 75.2 mm Hg, P<0.01) and decreased salbutamol-induced vasodilation compared to the Arg16/Arg16 genotype.
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