Why the study?
Does the Gly16 variant of the beta2-adrenoceptor gene associate with essential hypertension in African Caribbeans?
Population
217 individuals of African Caribbean origin from primary care on the island of St Vincent, comprising 136…
Comparison
Presence of the Gly16 variant of the… vs Normotensive controls / Arg16 allele
Design
Case-control
Authors
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Should not change hypertension care in African Caribbeans; leaves open replication and functional validation in prospective studies.
Does the Gly16 variant of the beta2-adrenoceptor gene associate with essential hypertension in African Caribbeans?
The Gly16 variant of the beta2-adrenoceptor gene is strongly associated with essential hypertension in African Caribbeans, providing a potential genetic mechanism for enhanced vascular reactivity in this population.
Kotanko et al. (1997) studied this question.
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