Why the study?
Low plasma renin activity hypertension is prevalent in Afro-Caribbean persons, and it is unknown whether an imbalance between the pressor and depressor axes of the renin angiotensin aldosterone system predisposes persons of African descent to hypertension.
Does an imbalance in the ACE2/Ang-(1-7)/Mas and ACE/Ang II/AT1 axes contribute to hypertension in Afro-Caribbean populations?
Population
30 normotensives and 30 recently diagnosed hypertensives aged 18-55 of Afro-Caribbean origin
Comparison
Recently diagnosed hypertensives naïve to antihypertensive treatment vs normotensives
Authors
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Supports hypothesis of RAAS imbalance in Afro-Caribbean low-renin hypertension; hypothesis-generating, needs prospective trials before clinical consideration.
Does an imbalance in the ACE2/Ang-(1-7)/Mas and ACE/Ang II/AT1 axes contribute to hypertension in Afro-Caribbean populations?
This study protocol outlines an investigation into whether an imbalance in RAAS axes predisposes Afro-Caribbean individuals to hypertension.
Cohall et al. (2020) studied this question.
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