February 1, 2000Journal of Hypertension
Association analysis of β2 adrenoceptor polymorphisms with hypertension in a Black African population
Why the study?
Is beta2 adrenoceptor polymorphism associated with the development of hypertension in a Black South African population?
Population
315 individuals of Black South African origin, comprising 192 unrelated hypertensives and 123 normotensives…
Comparison
Presence of beta2 adrenoceptor polymorphisms vs Absence of these polymorphisms
Design
Case-control
Authors
Discussion
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Member takes
Implication
No association in this population does not support genotyping for these variants in risk assessment; leaves open roles in other ancestries or hypertension subtypes.
Structured PICO
Is beta2 adrenoceptor polymorphism associated with the development of hypertension in a Black South African population?
P
Population
315 individuals of Black South African origin, comprising 192 unrelated hypertensives (recruited from hospital clinics in Gauteng) and 123 normotensives from the same community.
I
Intervention
Presence of beta2 adrenoceptor polymorphisms (Arg-Gly16 and Gln-Glu27)
C
Comparator
Absence of these polymorphisms (wild-type genotypes)
O
Outcome
Hypertension status
Beta2 adrenoceptor polymorphisms (Arg-Gly16 and Gln-Glu27) do not appear to be a risk factor for hypertension in the Black South African population.
Cite This Study
Candy et al. (2000) studied this question.