August 1, 2004American Journal of HypertensionOpen Access

Lack of association between polymorphism in the ?-adrenergic receptor gene, hypertension, and obesity in the Olivetti Heart Study

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Why the study?

Are Arg16Gly and Gln27Glu polymorphisms in the beta2 adrenoreceptor gene associated with hypertension and obesity in middle-aged men?

Population

993 middle-age adult white men from a general population sample, including 563 overweight, 160 obese, and…

Comparison

Presence of Arg16Gly and Gln27Glu polymorphisms… vs Different genotypes of the beta2AR gene

Design

Cross-sectional

Authors

FGFerruccio GallettiApple (Israel)RIRoberto IaconeCRISPR Therapeutics (Switzerland)EREliana RagoneInstitute of Food Science

Discussion

Member takes

Implication

No link to hypertension or obesity in this cross-sectional analysis; leaves open beta2AR variant effects in other populations or study designs.

Structured PICO

Are Arg16Gly and Gln27Glu polymorphisms in the beta2 adrenoreceptor gene associated with hypertension and obesity in middle-aged men?

Population

993 middle-age adult white men from a general population sample (Olivetti Heart Study), including 563 overweight, 160 obese, and 405 hypertensive individuals (171 on antihypertensive therapy).

Intervention

Presence of Arg16Gly and Gln27Glu polymorphisms in the beta2 adrenoreceptor (beta2AR) gene

Comparator

Different genotypes of the beta2AR gene (wild-type vs heterozygous vs homozygous variants)

Outcome

Association with body mass index, blood pressure, overweight, obesity, and hypertension

Genetic variation in the beta2AR gene (Arg16Gly and Gln27Glu polymorphisms) is not associated with blood pressure, overweight, or obesity in adult white men.

Cite This Study

Galletti et al. (2004) studied this question.

synapsesocial.com/papers/6a88435f8dfe8b7ec5a54071 https://doi.org/10.1016/j.amjhyper.2004.04.012

Topics

Hypertension management

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Implication

No link to hypertension or obesity in this cross-sectional analysis; leaves open beta2AR variant effects in other populations or study designs.

Lack of association between polymorphism in the ?-adrenergic receptor gene, hypertension, and obesity in the Olivetti Heart Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Lack of association between polymorphism in the ?-adrenergic receptor gene, hypertension, and obesity in the Olivetti Heart Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider