Key result
A single 250 mg oral dose of caffeine decreased the baroreflex slope from 31 to 11.6 msec/mm Hg at 30 minutes in young normotensive volunteers, whereas placebo had no significant effect.
Why the study?
Does oral caffeine alter blood pressure, heart rate, and baroreflex activation in young normotensive volunteers?
RCT (n=10)
Does oral caffeine alter blood pressure, heart rate, and baroreflex activation in young normotensive volunteers?
A single dose of caffeine acutely increases blood pressure and inhibits baroreflex activation in normotensive individuals, but these effects are not sustained with long-term ingestion.
No takes yet. Share an insight, caveat, or question.
Caffeine may acutely raise BP after abstinence; leaves open long-term CV effects and baroreflex role in larger cohorts.
Mosqueda‐Garcia et al. (1990) conducted an RCT in Normotensive volunteers (n=10). Caffeine vs. Placebo was evaluated on Baroreflex activation (elicited by phenylephrine). A single 250 mg oral dose of caffeine decreased the baroreflex slope from 31 to 11.6 msec/mm Hg at 30 minutes in young normotensive volunteers, whereas placebo had no significant effect.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: