Key result
Caffeine pretreatment raises preprandial blood pressure ~13%, preventing postprandial drops below baseline.
Why the study?
The effects of caffeine on the postprandial fall of blood pressure in the elderly were not well understood.
Does oral caffeine pretreatment prevent the postprandial fall of blood pressure in healthy elderly subjects?
Population
15 healthy elderly subjects, mean age 75.4 +/- 6.6 years
Comparison
Oral ingestion of 250 mg caffeine 60 min before breakfast vs placebo
Design
Double-blind placebo-controlled study
Follow-up
Postprandial period
Authors
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Supports pre-meal caffeine to prevent postprandial hypotension in elderly; provides first RCT confirmation in healthy subjects.
RCT (n=15)
Double-blind
Does oral caffeine pretreatment prevent the postprandial fall of blood pressure in healthy elderly subjects?
Caffeine pretreatment before meals may help prevent postprandial hypotension in the elderly by raising preprandial blood pressure.
Lenders et al. (1988) conducted an RCT in Healthy (n=15). Caffeine vs. Placebo was evaluated on Postprandial fall of blood pressure. Caffeine pretreatment (250 mg) increased preprandial blood pressure by 12.5%, preventing postprandial blood pressure from falling below baseline despite an unaltered postprandial decrease.
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