Key result
Caffeine prevents an ~11 mmHg postprandial SBP drop versus placebo, avoiding symptomatic hypotension.
Why the study?
Does 100 mg of caffeine prevent postprandial blood pressure reduction in frail elderly subjects?
Population
20 frail elderly subjects, mean age 84 (range 75-93 years).
Comparison
100 mg of caffeine administered after a… vs Placebo administered after a standardized 400…
Design
RCT, random-order, cross-over, double-blind
Follow-up
60 minutes
Authors
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May warrant pre-meal caffeine to prevent symptomatic postprandial hypotension in frail elderly; provides RCT confirmation in this population.
RCT (n=20)
Double-blind
random-order
Does 100 mg of caffeine prevent postprandial blood pressure reduction in frail elderly subjects?
Absolute Event Rate: 1% vs -11%
p-value: p=<0.05
A 100 mg dose of caffeine effectively attenuates postprandial falls in sitting blood pressure and prevents symptomatic postprandial hypotension in frail elderly individuals.
Heseltine et al. (1991) conducted an RCT in Frail elderly (n=20). Caffeine vs. Placebo was evaluated on Change in sitting systolic blood pressure at 60 minutes post-drink (p=<0.05). Caffeine (100 mg) significantly attenuated the postprandial fall in sitting systolic blood pressure compared to placebo (1 mmHg vs -11 mmHg; P<0.05) and prevented symptomatic hypotension.
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