August 1, 1994Clinical Science
Haemodynamic and Neurohumoral Effects of Caffeine in Elderly Patients with Symptomatic Postprandial Hypotension: A Double-Blind, Randomized, Placebo-Controlled Study
Key result
Oral caffeine (250 mg) given with a meal did not significantly reduce the fall in supine mean arterial blood pressure compared to placebo (31 vs 19 mmHg fall) in symptomatic elderly patients.
Why the study?
Does oral caffeine prevent postprandial hypotension in elderly patients with symptomatic postprandial hypotension?
Population
9 elderly patients with histories of symptomatic postprandial hypotension, mean age 76 +/- 9 years.
Comparison
Caffeine 250 mg oral given with a standardized… vs Matching placebo given with a standardized…
Design
RCT, randomized, cross-over, double-blind, placebo-controlled
Follow-up
30 minutes post-meal
Authors
Discussion
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Implication
Caffeine should not be used to prevent postprandial hypotension in symptomatic elderly patients; challenges prior assumptions and supports alternative strategies in future trials.
Study Design
Type
RCT (n=9)
Blinding
Double-blind
Randomization
Cross-over
Structured PICO
Does oral caffeine prevent postprandial hypotension in elderly patients with symptomatic postprandial hypotension?
P
Population
9 elderly patients (mean age 76 years) with a history of symptomatic postprandial hypotension.
I
Intervention
Caffeine 250 mg oral given with a standardized 1674kJ liquid meal.
C
Comparator
Matching placebo given with a standardized 1674kJ liquid meal (cross-over design, at least 1 week apart).
O
Outcome
Supine mean arterial blood pressure and splanchnic blood volume at 30 minutes post-meal.surrogate
Main Result
Absolute Event Rate: 31% vs 19%
p-value: p=not significant
Oral caffeine does not prevent postprandial hypotension or reduce splanchnic blood pooling in symptomatic elderly patients.
Cite This Study
Lipsitz et al. (1994) conducted an RCT in Symptomatic postprandial hypotension (n=9). Caffeine vs. Placebo was evaluated on Fall in supine mean arterial blood pressure (p=not significant). Oral caffeine (250 mg) given with a meal did not significantly reduce the fall in supine mean arterial blood pressure compared to placebo (31 vs 19 mmHg fall) in symptomatic elderly patients.